guidelines for weight-loss.

The researchers analyzed various studies investigating nine Food and Drug Administration (FDA)-approved anti-obesity medications to treat adults with a body mass index (BMI) of 27 and above.

After analyzing the results, the researchers found that four drugs approved for long-term use have moderate or large weight loss effects with few negative side effects. The drugs were:

  • semaglutide, 2.4 milligrams (mg)

  • liraglutide, 3 mg

  • phentermine-topiramate extended-release (ER)

  • naltrexone-bupropion ER.

They noted that, when used alongside lifestyle interventions, each of the drugs was linked to a total body weight loss of between 3% and 10.8%.

Some studies also reported 15% total body weight loss..

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